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J Neuroimmunol. 1999 Jan 1;93(1-2):1-7.

Cell surface expression of MHC molecules in glioma cells infected with herpes simplex virus type-1.

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Department of Surgery, University of British Columbia, Vancouver, Canada.


9L glioma cells consistently expressed major histocompatibility complex (MHC) class I but not class II molecules. Herpes simplex type-1 virus (HSV-1) infection significantly reduced the expression of MHC I on the cell surface. Recombinant interferons could enhance the cell-surface expression of MHC I but had no effect on MHC II. This enhancement was partially inhibited by HSV-1 infection. HSV-1 mutants with deletions in ICP4, ICP6, ICP27, ICP47 and UL41 genes do not affect the infection induced inhibition, suggest that a different mechanism may be employed in the inhibition of cell-surface expression of MHC molecules.

[Indexed for MEDLINE]

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