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Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7394-7.

Neurosecretory control of aging in Caenorhabditis elegans.

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Molecular and Cellular Biology Program of the University of Washington and Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98195, USA.

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  • Proc Natl Acad Sci U S A 1999 Sep 14;96(19):10944.


In the nematode Caenorhabditis elegans, an insulin receptor signaling pathway regulates adult life span and developmental arrest at the dauer larval stage. Here we show that the unc-64 and unc-31 genes also function in this pathway. These two genes are involved in mediating Ca2+-regulated secretion. Mutations in unc-64 and unc-31 increase adult life span and cause constitutive dauer formation. Both phenotypes are suppressed by mutations in daf-16, which also suppresses other mutations in this pathway. We present evidence that the site of action of unc-64 is neuronal, suggesting that a neurosecretory signal regulates life span and dauer formation.

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