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Curr Opin Genet Dev. 1999 Jun;9(3):333-7.

Cellular and molecular mechanisms of memory: the LTP connection.

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Department of Neurosciences University of California San Diego School of Medicine 9500 Gilman Drive, La Jolla, California 92093-0691, USA.


Studies of the cellular and molecular mechanisms of memory formation have focused on the role of long-lasting forms of synaptic plasticity such as long-term potentiation (LTP). A combination of genetic, electrophysiological and behavioral techniques have been used to examine the possibility that LTP is a cellular mechanism of memory storage in the mammalian brain. Although a definitive answer remains elusive, it is clear that in many cases manipulations that alter LTP alter memory, and training regimens that produce memory can produce LTP-like potentiation of synaptic transmission.

[Indexed for MEDLINE]

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