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Curr Opin Genet Dev. 1999 Jun;9(3):346-54.

The roles of RNA-binding proteins in spermatogenesis and male infertility.

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Department of Biochemistry University of Leicester University Road, Leicester, LE1 7RH, UK.


RNA-binding proteins are essential for spermatogenesis: they are required in the nucleus of germ cells, for the production of specific mRNA isoforms, and in the cytoplasm - where proteins required for chromatin condensation and for changes in cell morphology are translated long after transcription ceases. Some of the RNA targets and the RNA-binding proteins themselves have been identified recently. Both nuclear and cytoplasmic proteins are affected in examples of azoospermia in men.

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