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Br J Cancer. 1999 Jun;80(8):1262-4.

Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients.

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1
Department of Medical Oncology, Clinica Puerta de Hierro, Madrid, Spain.

Abstract

Hypermethylation of exon 1 of p16INK4a was examined in tumour and plasma DNA of a series of breast cancer patients. De novo methylation was observed in the tumours of eight patients (23%), and in plasma DNA in five (14%) of these eight patients. Our data show that de novo methylation of exon 1 of p16INK4a can be demonstrated in plasma DNA of breast cancer patients, a fact that provides additional evidence of the tumour-related origin of free plasma DNA in cancer patients.

PMID:
10376981
PMCID:
PMC2362379
DOI:
10.1038/sj.bjc.6690495
[Indexed for MEDLINE]
Free PMC Article
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