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FEBS Lett. 1999 Jun 4;452(1-2):100-3.

Lipid signaling in CD95-mediated apoptosis.

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Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Italy.


Ceramides play an important role mediating different cell responses such as proliferation, differentiation, growth arrest and apoptosis. They are released upon sphingomyelin hydrolysis which occurs after triggering of a number of cell surface receptors including CD95. Ceramide generation also regulates glycosphingolipid and ganglioside metabolism. In particular, ganglioside GD3 biosynthesis represents an important event for the progression of apoptotic signals generated by CD95 and mediated by ceramide in hematopoietic cells.

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