Transfer RNA modification: influence on translational frameshifting and metabolism

FEBS Lett. 1999 Jun 4;452(1-2):47-51. doi: 10.1016/s0014-5793(99)00528-1.

Abstract

Transfer RNA modification improves the rate of aa-tRNA selection at the A-site and the fitness in the P-site and thereby prevents frameshifting according to a new model how frameshifting occurs [Qian et al. (1998) Mol. Cell 1, 471-482]. Evidence that the presence of various modified nucleosides in tRNA also influences central metabolism, thiamine metabolism, and bacterial virulence is reviewed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Frameshifting, Ribosomal / genetics
  • Frameshifting, Ribosomal / physiology*
  • RNA, Bacterial / genetics
  • RNA, Bacterial / metabolism
  • RNA, Transfer / genetics
  • RNA, Transfer / metabolism*

Substances

  • RNA, Bacterial
  • RNA, Transfer