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FEBS Lett. 1999 Jun 4;452(1-2):47-51.

Transfer RNA modification: influence on translational frameshifting and metabolism.

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Department of Microbiology, Umeå University, Sweden.


Transfer RNA modification improves the rate of aa-tRNA selection at the A-site and the fitness in the P-site and thereby prevents frameshifting according to a new model how frameshifting occurs [Qian et al. (1998) Mol. Cell 1, 471-482]. Evidence that the presence of various modified nucleosides in tRNA also influences central metabolism, thiamine metabolism, and bacterial virulence is reviewed.

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