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Brain Res. 1999 Jul 3;833(2):291-6.

In vivo microdialysis measures of extracellular serotonin in the rat hippocampus during sleep-wakefulness.

Author information

1
Department of Neurology, Kyungpook National University School of Medicine, Taegu 700-412, South Korea.

Abstract

We investigated extracellular 5-hydroxytryptamine (5-HT) levels in rat hippocampus during different stages of the sleep-waking cycle using in vivo microdialysis. The extracellular 5-HT level was highest in active waking (AW) and, when compared to AW, 5-HT level was progressively lower in quiet waking (QW; 78%), quiet sleep (QS; 50%) and REM (which we termed active sleep (AS); 40%). Functional implications of AS related-decreased 5-HT in the hippocampus are discussed.

PMID:
10375707
DOI:
10.1016/s0006-8993(99)01511-5
[Indexed for MEDLINE]

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