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Curr Opin Immunol. 1999 Jun;11(3):346-51.

IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men.

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1
Institut National de la Santé et de la Recherche Médicale Unité 429,Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75015, Paris, France, EU.

Abstract

The development of gene-knockout mice and the identification of gene-deficient humans have improved our understanding of the role of IL-12 and IFN-gamma in host defense. Comparison of experimental and natural infections has shown that animals and humans genetically deficient in immunity mediated by IL-12 or IFN-gamma are highly susceptible to mycobacteria and salmonella. Impaired secretion of, or response to, IFN-gamma is the common pathogenic mechanism that accounts for impaired granuloma formation and uncontrolled growth of bacteria within macrophages. The axis formed between IL-12 and IFN-gamma is essential for protective immunity against mycobacteria and salmonella in mice and men.

PMID:
10375558
[Indexed for MEDLINE]

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