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Curr Opin Immunol. 1999 Jun;11(3):319-25.

Chemokine receptors in lymphoid organ homeostasis.

Author information

1
Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA. jung@saturn.med.nyu.edu

Abstract

Leukocytes respond to complex patterns of chemoattractant cytokine (chemokine) gradients that guide them to their destinations in secondary lymphoid organs. This directed movement of multiple cell types requires the choreographed expression of specific G-protein-coupled chemokine receptors and both positive and negative regulation of the signal transduction pathways emanating from them.

PMID:
10375556
DOI:
10.1016/s0952-7915(99)80051-x
[Indexed for MEDLINE]

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