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Curr Opin Immunol. 1999 Jun;11(3):242-8.

T cell antigen-receptor signal transduction.

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National Cancer Institute, Building 37, Room 1E24, Laboratory of Cellular and Molecular Biology, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.


During the past year, major progress has been made in understanding proximal TCR signal-transduction events. Cbl has been identified as a negative regulator of kinases from the ZAP-70/Syk family. Studies on LAT, SLP-76, Itk and Vav have revealed their role in the activation of Ras and phospholipase-Cgamma1-Ca2+ signalling pathways. TCR-induced cytoskeletal changes involve signalling through SLP-76-Vav-Nck to activate effectors of the Rho-family of GTPases. Finally, glycolipid-enriched microdomains play a crucial role in T cell activation.

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