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Curr Opin Immunol. 1999 Jun;11(3):286-93.

T cell co-stimulatory molecules other than CD28.

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University of Toronto, Department of Immunology, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada.


CD28 is the primary co-stimulatory receptor for inducing high-level IL-2 production and survival of naïve CD4(+) T cells. While no other cell surface receptor can be considered fully redundant with CD28, recent developments suggest that additional co-stimulatory pathways have preferential effects at different stages of T cell activation, on different subsets of T cells or contribute to the development of different effector functions.

[Indexed for MEDLINE]

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