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Curr Biol. 1999 Jun 17;9(12):R443-5.

Insulin secretion: feed-forward control of insulin biosynthesis?

Author information

1
Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK. g.a.rutter@bris.ac.uk

Abstract

It has long been accepted wisdom that insulin secreted from islet beta cells has either no effect, or an inhibitory feedback effect, on insulin synthesis and secretion. Recent work suggests, instead, that secreted insulin acts directly on beta cells, via its own receptor, to enhance insulin production in an autocrine feed-forward loop.

PMID:
10375519
DOI:
10.1016/s0960-9822(99)80277-2
[Indexed for MEDLINE]
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