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Brain Res Bull. 1999 Mar 15;48(5):539-43.

Induction of presenilins in the rat brain after middle cerebral arterial occlusion.

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1
Department of Pharmacology and Therapeutics, University of South Florida, College of Medicine, Tampa 33612, USA. kpennypa@pharm1.med.usf.edu

Abstract

In the present study, we have examined the expression of both presenilins in the rat hippocampus, cortex, striatum, and cerebellum after middle cerebral artery occlusion (MCA-O), an animal model of ischemia. The cortex showed the greatest increase in PS mRNA levels (7-10-fold) at 4 and 8 days posttreatment. Presenilin-1 (PS-1) levels in the contralateral cortex were significantly increased 1 day after MCA-O. In comparison, PS mRNA content was only modestly elevated in the hippocampus and striatum at 4 and 8 days after MCA-O (30-100% changes). Other Alzheimer's disease (AD)-related genes, amyloid precursor protein and apolipoprotein E, are induced in brain injury suggesting that these AD-related genes may well be components of a brain-injury response. Thus, a breakdown in this response via cerebrovascular disease and/or genetic mutation may contribute to AD pathology.

PMID:
10372515
[Indexed for MEDLINE]
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