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Ann N Y Acad Sci. 1999 Apr 30;872:211-7; discussion 217-9.

Absence of CD34 on some human SCID-repopulating cells.

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Program in Cancer, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.


The availability of in vivo repopulation assays has greatly aided the study of human hematopoietic stem cells. Here, I shall review recent data that has identified a novel class of human repopulating cells that do not express classical stem cell markers including CD34 but still retain the ability to repopulate nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice.

[Indexed for MEDLINE]

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