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Arzneimittelforschung. 1976;26(10a):1907.

The synthesis of ethyl apovincaminate.

Abstract

Starting from (+) vincamine (I), simple derivatives of vincaminic acid (II), apovincaminic acid (V) and apovincaminol (VII) were synthetized. Out of these the synthesis of ethyl apovincaminate (Cavinton), as a representative, is described in detail. The water elimination and esterification of II can be carried out in one step.

PMID:
1037211
[Indexed for MEDLINE]

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