The synthesis of ethyl apovincaminate

Arzneimittelforschung. 1976;26(10a):1907.

Abstract

Starting from (+) vincamine (I), simple derivatives of vincaminic acid (II), apovincaminic acid (V) and apovincaminol (VII) were synthetized. Out of these the synthesis of ethyl apovincaminate (Cavinton), as a representative, is described in detail. The water elimination and esterification of II can be carried out in one step.

MeSH terms

  • Vasodilator Agents
  • Vinca Alkaloids / chemical synthesis*

Substances

  • Vasodilator Agents
  • Vinca Alkaloids