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Folia Med (Plovdiv). 1998;40(4):65-70.

Erythrocyte ferritin levels in chronic renal failure patients.

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1
Department of Radiology, Higher Medical Institute, Plovdiv, Bulgaria.

Abstract

The authors studied the level of erythrocyte ferritin and its importance as a marker of iron metabolism in renal anemia patients.

METHODS:

We studied 33 chronic renal failure patients--12 men and 21 women, aged 33-72 years. Hemoglobin levels, erythrocyte counts, hematocrit, mean corpuscular hemoglobin, serum creatinine, iron and ferritin in serum and erythrocytes were measured on a regular basis throughout the study period employing the monoclonal IRMA "Micromedic" kit.

RESULTS:

Serum iron levels were significantly lower in first degree chronic renal failure (CRF) patients (11.07 +/- 1.54 mmol/l) as compared with the controls (P < 0.01) whereas serum (91.10 +/- 4.00 ng/ml) and erythrocyte (0.83 +/- 0.08 ng/g Hb) ferritin levels were within normal limits. There was a moderately positive correlation (r = 0.37) between serum and erythrocyte ferritin levels. In second and third degree CRF patients the serum iron (7.82 +/- 0.72 mmol/l), serum ferritin (77.60 +/- 3.24 ng/ml) and erythrocyte (0.71 +/- 0.06 ng/g Hb) ferritin levels were significantly lower as compared with those of first degree CRF patients. In the hemodialysis patients erythrocyte ferritin levels showed a tendency towards increase as compared with those in second and third degree CRF patients (P < 0.05). There was a moderately negative correlation (r = -0.44) between serum iron and erythrocyte ferritin levels in this group of patients.

CONCLUSIONS:

1. Erythrocyte ferritin levels can be useful in the complex diagnostic assessment of the anemic syndrome in CRF patients. 2. Erythrocyte ferritin is a reliable indicator of iron overload in hemodialysis patients. 3. Erythrocyte ferritin gives no advantage in the evaluation of iron metabolism of medically treated CRF patients.

PMID:
10371803
[Indexed for MEDLINE]
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