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Bull Acad Natl Med. 1999;183(2):277-86; discussion 286-7.

[Apoptosis and cancer].

[Article in French]

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Département d'Anatomopathologie, Faculté de Médecine, Université de Ioannina, Grèce.


Apoptosis or programmed cell death is a form of regulated cell death that represents an important biological principle in tissue development and homeostasis. Its regulation appears to be perturbed in several major diseases, including cancer. The control of cell death events is extremely complex at the genetic and biochemical levels. It has been suggested that genes or factors that suppress apoptosis are essential components of carcinogenesis. The complete mechanisms implicated in apoptosis remains an issue for a future investigation. Details of how the death pathway itself is initiated, will provide a firm basis for the development of agents capable of eliciting the process in chemoresistant tumours.

[Indexed for MEDLINE]

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