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Neurogenetics. 1999 Apr;2(2):129-31.

5-HTTLPR variants not associated with autistic spectrum disorders.

Author information

1
Department of Human Genetics, New York State Institute for Basic Research, 1050 Forest Hill Road, Staten Island, NY 10314, USA. omrddzhong@aol.com

Abstract

To determine whether there is an association of polymorphic variants of the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) and autistic spectrum disorders, we analyzed the 5-HTTLPR genotypes of 72 autistic subjects, 11 fragile X syndrome patients with autistic behavior, 43 normal subjects, and 49 fragile X syndrome non-autistic subjects. The distribution frequency of 5-HTTLPR long allele (L) and the short allele (S) variants showed no differences between subjects. Our findings do not support the hypothesis that polymorphic 5-HTTLPR variants are a susceptibility factor for autistic disorders.

PMID:
10369890
[Indexed for MEDLINE]

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