Send to

Choose Destination
J Mol Evol. 1999 Jul;49(1):98-107.

Is there a phylogenetic signal in prokaryote proteins?

Author information

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.


Using the sequence information from nine completely sequenced bacterial genomes, we extract 32 protein families that are thought to contain orthologous proteins from each genome. The alignments of these 32 families are used to construct a phylogeny with the neighbor-joining algorithm. This tree has several topological features that are different from the conventional phylogeny, yet it is highly reliable according to its bootstrap values. Upon closer study of the individual families used, it is clear that the strong phylogenetic signal comes from three families, at least two of which are good candidates for horizontal transfer. The tree from the remaining 29 families consists almost entirely of noise at the level of bacterial phylum divisions, indicating that, even with large amounts of data, it may not be possible to reconstruct the prokaryote phylogeny using standard sequence-based methods.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center