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Radiother Oncol. 1999 Feb;50(2):199-204.

Impact of localized radiotherapy on blood immune cells counts and function in humans.

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  • 1Department of Radiation Oncology, Eberhard Karls University Tübingen, Germany.


Immune cells subsets were prospectively analyzed after localized radiotherapy (LRT). LRT reduced the levels of all lymphocyte subsets, with B-cells and naive T-cells being most sensitive. Lymphocyte function was suppressed, but still within the normal range. Rapid recovery of cytotoxic T-cells/natural killer cells after LRT and the functional suppression within normal levels explains the low incidence of infections after LRT.

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