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Biochim Biophys Acta. 1999 Jun 9;1445(3):337-41.

Identification of a 24 kDa intrinsic membrane protein from mammalian peroxisomes.

Author information

1
Unidade de Neurobiologia Genética do Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.

Abstract

A 24 kDa protein from rat liver peroxisomal membrane was isolated and subjected to Edman degradation. Using the N-terminal sequence of this polypeptide we have identified several rat and human expressed sequence tags in the GenBank Database. The complete sequence of a human cDNA clone was determined. The open reading frame encodes an extremely basic protein 212 amino acid residues long. A high similarity between this mammalian protein and hypothetical proteins from Caenorhabditis elegans and Neurospora crassa was found. Hydropathy analysis reveals the existence of two putative membrane-spanning domains in conserved regions of the three homologous proteins.

PMID:
10366717
DOI:
10.1016/s0167-4781(99)00061-5
[Indexed for MEDLINE]

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