Send to

Choose Destination
See comment in PubMed Commons below
Int J Gynaecol Obstet. 1999 Mar;64(3):253-8.

Tetanus toxoid and congenital abnormalities.

Author information

  • 1Department of Human Genetics and Teratology, National Institute of Public Health-WHO Collaborating Centre for the Community Control of Hereditary Diseases, Budapest, Hungary.



To study the human teratogenic potential of tetanus vaccination during pregnancy.


Pair analysis of cases with congenital abnormalities and matched healthy controls was performed in the large population-based dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1994.


Of 35 727 pregnant women who had babies without any defects in the study period (control group), 33 (0.09%) were vaccinated with tetanus. Of 21563 pregnant women who had offspring with congenital abnormalities, 25 (0.12%) had tetanus vaccination. This difference was not significant (P = 0.39). The case-control pair analysis confirmed the safety of tetanus vaccination during pregnancy, particularly in the second and third months of gestation, i.e. during the critical period for congenital abnormalities.


Tetanus vaccination during pregnancy appears not be teratogenic to the fetus. Thus, there is no contraindication, if the use of tetanus toxoid is necessary during pregnancy.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center