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Curr Opin Struct Biol. 1999 Jun;9(3):374-82.

From protein structure to function.

Author information

1
Biomolecular Structure and Modelling Unit, Department of Biochemistry, University College London, UK. cath@biochem.ucl.ac.uk

Abstract

Several databases of protein structural families now exist-organised according to both evolutionary relationships and common folding arrangements. Although these lag behind sequence databases in size, the prospect of structural genomics initiatives means that they may soon include representatives of many of the sequence families. To some extent, functional information can be derived from structural similarity. For some structural families, their function is highly conserved, whereas, for others, it can only be inherited or derived on the basis of additional information (e.g. sequence patterns, common residue clusters and characteristic surface properties).

PMID:
10361094
DOI:
10.1016/S0959-440X(99)80051-7
[Indexed for MEDLINE]

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