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Fertil Steril. 1999 Jun;71(6):1144-6.

Influence of advanced age on the blastocyst development rate and pregnancy rate in assisted reproductive technology.

Author information

1
Centre for Human Reproduction, Athens, Greece. pantos@iname.com

Abstract

OBJECTIVE:

To evaluate the percentage of blastocysts developing, the pregnancy rate, the implantation rate, and the abortion rate in women >40 years of age using a cell-free culture system for the development of viable human blastocysts.

DESIGN:

Retrospective clinical study.

SETTING:

Private IVF units.

PATIENT(S):

Two hundred ninety-three cycles in patients undergoing IVF treatment for infertility. Sixty-two cycles were in patients > or =40 years of age, and 231 cycles were in patients <40 years of age.

INTERVENTION(S):

Pronucleate oocytes obtained from IVF were cultured in vitro for 5-6 days. One to four embryos were transferred.

MAIN OUTCOME MEASURE(S):

Blastocyst development rate, pregnancy rate, implantation rate, and abortion rate.

RESULT(S):

From 293 cycles, 3,115 pronucleate oocytes were cultured, producing 1,175 blastocysts. In the women >40 years of age, the blastocyst development rate was 22.2%, and in the younger group, the rate was 40.5%. The pregnancy rate and implantation rate in the > or =40-year age group were 21.1% and 8.9%, respectively; corresponding rates in the younger group were 44.6% and 19.9%. The abortion rate was increased for the > or =40-year age group (25% versus 13.3%).

CONCLUSION(S):

Success rates for the development of viable human blastocysts, pregnancy, and implantation decline significantly in women > or =40 years old.

PMID:
10360925
[Indexed for MEDLINE]

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