Format

Send to

Choose Destination
Bioorg Med Chem Lett. 1999 May 17;9(10):1459-62.

Synthesis and structure-activity relationship of novel glycylcycline derivatives leading to the discovery of GAR-936.

Author information

1
Chemical Sciences, Wyeth-Ayerst Research, Pearl River, New York 10965, USA.

Abstract

A number of new glycylcyclines were synthesized for structure-activity relationship study. Many of the derivatives exhibit potent, broad spectrum antibacterial activity against both tetracycline susceptible and resistant organisms. GAR-936 (TBG-MINO) shows better activity than the previously reported DMG-MINO and DMG-DMDOT.

PMID:
10360756
DOI:
10.1016/s0960-894x(99)00216-4
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center