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Bioorg Med Chem Lett. 1999 May 17;9(10):1379-84.

N-substituted-3-arylpyrrolidines: potent and selective ligands at serotonin 1A receptor.

Author information

1
Department of Chemistry and Center for Biofunctional Molecules, POSTECH, Pohang, Korea. ahn@vision.postech.ac.kr

Abstract

3-Arylpyrrolidines are synthesized through the coupling of N-benzyl-3-(methanesulfonyloxy)pyrrolidine with diarylcuprates. Pharmacological evaluation of a series of N-substituted-3-arylpyrrolidines toward several neurotransmitter receptors indicated that some of them are good ligands for serotonin 1A receptor. Particularly, N-[(N-saccharino)butyl]pyrrolidines were found to be potent and selective ligands. A preliminary biological evaluation for several selected compounds indicated that they are potentially effective antianxiety and antidepressant agents.

PMID:
10360740
DOI:
10.1016/s0960-894x(99)00201-2
[Indexed for MEDLINE]

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