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Bioorg Med Chem Lett. 1999 May 17;9(10):1361-4.

S1319: a novel beta2-andrenoceptor agonist from a marine sponge Dysidea sp.

Author information

1
Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Takasaki, Gunma, Japan.

Abstract

In the course of screening of potential leads for beta2-receptor agonists, we found a novel beta2-adrenoceptor selective agonist, S1319, from a marine sponge Dysidea sp. The active compound was isolated and structurally characterized as 4-hydroxy-7-[1-(1-hydroxy-2-methylamino)ethyl]-1,3-benzothiazole-2(3H)-o ne, a new member of the beta2-adrenoceptor agonist. This is the first example of a sponge-derived beta2-adrenoceptor agonist.

PMID:
10360736
DOI:
10.1016/s0960-894x(99)00205-x
[Indexed for MEDLINE]

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