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Curr Biol. 1999 Jun 3;9(11):R403-7.

Multidrug resistance: Versatile drug sensors of bacterial cells.

Author information

1
Biotechnology Center, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA.

Abstract

One way that bacteria resist antimicrobial agents involves 'drug sensors', proteins that bind a range of structurally unrelated antimicrobial drugs and induce expression of multidrug resistance pumps. The basis for drug recognition is now becoming clear from the recently determined crystal structure of a drug sensor.

PMID:
10359693
DOI:
10.1016/s0960-9822(99)80254-1
[Indexed for MEDLINE]
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