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Eur J Immunol. 1999 May;29(5):1421-5.

CIIV, MIIC and other compartments for MHC class II loading.

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Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam.


Virtually every endocytic compartment has been claimed to be an MIIC, a site where class II molecules accumulate. Here, it is argued that the definition of MIIC is not accurate and often pointless. MIIC can better be used as a working title for a collection of late endocytic compartments that contain the goodies necessary for efficient peptide loading of class II molecules.

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