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Ann Intern Med. 1999 May 4;130(9):740-3.

Compassionate use of continuous prostacyclin in the management of secondary pulmonary hypertension: a case series.

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1
Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, USA.

Abstract

BACKGROUND:

Treatment of patients with secondary pulmonary hypertension has been unsatisfactory.

OBJECTIVE:

To describe exercise capacity, functional class, and hemodynamic variables after long-term intravenous infusion of prostacyclin in patients with secondary pulmonary hypertension.

DESIGN:

Case series.

SETTING:

Academic referral center.

PATIENTS:

33 patients with secondary, precapillary pulmonary hypertension (New York Heart Association class III or IV).

INTERVENTION:

Continuous intravenous prostacyclin administered by portable infusion pump on a compassionate-use basis.

MEASUREMENTS:

Functional class, treadmill time, and hemodynamic variables.

RESULTS:

Patients were followed for an average of 12.7 +/- 5.6 months. Exercise tolerance and New York Heart Association class improved in each patient. The duration of treadmill exercise increased from 186 seconds to 491 seconds, an increase of 305 seconds (95% CI, 194 to 417 seconds; P < 0.001). Mean pulmonary artery pressure decreased from 60 mm Hg to 46 mm Hg, a decrease of 14 mm Hg (CI, 9 to 19 mm Hg; P < 0.001). Cardiac output increased from 3.90 L/min to 6.30 L/min, an increase of 2.40 L/min (CI, 1.56 to 3.25 L/min; P < 0.001). The pulmonary vascular resistance decreased from 1143 dynes x s/cm5 to 575 dynes x s/cm5, a decrease of 567 dynes x s/cm5 (CI, 407 to 727 dynes x s/cm5; P < 0.001). Patients with collagen vascular disease, congenital heart disease, and portopulmonary hypertension were analyzed with other patients and separately. All groups had a statistically significant reduction in mean pulmonary artery pressure and a statistically significant increase in cardiac output.

CONCLUSION:

Intravenous prostacyclin may be effective in the treatment of patients with certain types of secondary pulmonary hypertension.

PMID:
10357693
[Indexed for MEDLINE]
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