Format

Send to

Choose Destination
Trends Pharmacol Sci. 1999 May;20(5):205-10.

The interactions of adenylate cyclases with P-site inhibitors.

Author information

1
Department of Integrative Biology, Pharmacology and Physiology, University of Texas Health Science Center at Houston, Houston, TX, USA.

Abstract

Recent kinetic, binding and crystallographic studies using P-site inhibitors of mammalian adenylate bases provide new insights into the catalytic mechanism of these highly regulated enzymes. Here, Carmen Dessauer and colleagues discuss the conformational states of adenylate cyclase, the structural determinants of inhibitor binding and the potential uses of these inhibitors as pharmacological agents.

PMID:
10354616
DOI:
10.1016/s0165-6147(99)01310-3
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center