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Trends Cell Biol. 1999 Jun;9(6):228-33.

Cytoskeletal rearrangement during migration and activation of T lymphocytes.

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Servico de Immunolog a, Hospital de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain.


T lymphocytes have an inherent ability to migrate along a chemotactic gradient, which enables them to exit the bloodstream and reach different tissues. Motile T cells display a polarized morphology with two distinct cell compartments: the leading edge and the uropod. During cell polarization, chemoattractant receptors, cell-adhesion molecules and cytoskeletal proteins are redistributed within these cellular compartments. The polarity of T lymphocytes changes during the establishment of antigen-specific cell-cell interactions, and this involves rearrangement of cytoskeletal proteins. This article discusses the regulation of these cytoskeletal rearrangements, and their role in the activation, migration and effector function of T cells.

[Indexed for MEDLINE]

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