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Trends Cell Biol. 1999 Jun;9(6):207-10.

All aboard the cyclin train: subcellular trafficking of cyclins and their CDK partners.

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Dept of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3686, C366 LSRC, Durham, NC 27710, USA.


Progression through the cell cycle is governed by the periodic activation and inactivation of cyclin-dependent kinase complexes (CDK-cyclins). Although the enzymatic activity of these complexes is regulated tightly, it has recently been demonstrated that an additional facet of cell-cycle control involves the modulation of CDK-cyclin subcellular localization. Recent discoveries include the identification of nuclear transport factors responsible for ferrying some of the CDK-cyclins in and out of the nucleus, the demonstration that phosphorylation can regulate these transport processes and the establishment of potential links between cell-cycle checkpoints and the control of CDK-cyclin subcellular localization.

[Indexed for MEDLINE]

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