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Immunol Today. 1999 Jun;20(6):285-8.

Structure and evolution of the extended B7 family.

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CNRS ER1794, Faculté de Médecine 87025 Limoges, France.


Here, Joëlle Henry and colleagues explore structural and evolutionary relationships between the B7 costimulator molecules and a growing number of molecules encoded within the major histocompatibility complex. They propose that B7 and MHC genes are derived from a common ancestor, with several members of this large gene family possibly having pivotal influences on T-cell activation.

[Indexed for MEDLINE]

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