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Br J Haematol. 1999 Jun;105(3):616-7.

Serum G-CSF levels are not increased in patients with antibody-induced neutropenia unless they are suffering from infectious diseases.

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Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig University Giessen, Germany.


By the use of a G-CSF-specific ELISA we determined the serum granulocyte-colony stimulating factor (G-CSF) levels in 63 patients with antibody-induced neutropenia including neonatal immune neutropenia, autoimmune neutropenia, and drug-induced immune neutropenia. In the sera of 20 patients, elevated G-CSF levels of 60-1006 pg/ml (normal <39 pg/ml) were observed. These patients suffered from infectious diseases at the time of blood collection. G-CSF levels normalized after successful antibiotic treatment, indicating that increased G-CSF production in patients with immune neutropenia may be primarily the result of infection and not of neutropenia.

[Indexed for MEDLINE]

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