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Ann Allergy Asthma Immunol. 1999 May;82(5):504-6.

Hilar adenopathy in allergic bronchopulmonary aspergillosis.

Author information

1
Department of Clinical Research, Vallabhbhai Patel Chest Institute, University of Delhi, India.

Erratum in

  • Ann Allergy Asthma Immunol 1999 Jun;82(6):542.

Abstract

BACKGROUND:

A 20-year-old male student developed allergic bronchopulmonary aspergillosis (ABPA). Computed tomography (CT) of the thorax done to detect central bronchiectasis (CB) for confirmation of diagnosis revealed, in addition, right hilar lymphadenopathy. Hilar adenopathy is thought to be rare in ABPA and has been documented only once before. Because of the finding of hilar adenopathy, the earlier reported patient had to undergo an invasive surgical procedure.

OBJECTIVE:

To report a case of true hilar adenopathy in ABPA.

METHODS:

This is a single case report. Contrast enhanced CT of the thorax was done. Serum precipitating antibodies against Aspergillus fumigatus were tested using gel diffusion technique, and intradermal testing with antigens of Aspergillus species was performed. Specific IgG antibodies against A. fumigatus and total IgE levels were measured by ELISA.

RESULTS:

A review of serial chest radiographs over a period of 3 years demonstrated transient pulmonary infiltrates and right hilar prominence. Computed tomography of the thorax revealed right hilar lymphadenopathy along with bilateral central bronchiectasis and patchy infiltrates. Strong bands of precipitins were detected against A. fumigatus. Intradermal testing with antigens of Aspergillus species elicited strong type I (immediate) and type III (Arthus-type) hypersensitivity reactions to A. fumigatus and A. niger. Specific IgG antibodies against A. fumigatus was positive and total IgE level was significantly elevated. Peripheral blood eosinophilia was also detected.

CONCLUSIONS:

Although extremely rare, ABPA should be considered in the differential diagnosis of hilar adenopathy.

PMID:
10353584
DOI:
10.1016/S1081-1206(10)62729-9
[Indexed for MEDLINE]

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