Format

Send to

Choose Destination
J Antimicrob Chemother. 1999 Apr;43(4):447-58.

Inhibitor-resistant TEM beta-lactamases: phenotypic, genetic and biochemical characteristics.

Author information

1
UMR 175, CNRS-MNHN, Quimper, France.

Abstract

Beta-lactamases represent the main mechanism of bacterial resistance to beta-lactam antibiotics. The recent emergence of bacterial strains producing inhibitor-resistant TEM (IRT) enzymes could be related to the frequent use of beta-lactamase inhibitors such as clavulanic acid, sulbactam and tazobactam in hospitals and in general practice. The IRT beta-lactamases differ from the parental enzymes TEM-1 or TEM-2 by one, two or three amino acid substitutions at different locations. This paper reviews the phenotypic, genetic and biochemical characteristics of IRT beta-lactamases in an attempt to shed light on the pressures that have contributed to their emergence.

PMID:
10350372
DOI:
10.1093/jac/43.4.447
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center