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Biomed Pharmacother. 1999 Apr;53(3):122-30.

Pesticides and Parkinson's disease.

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1
Canberra Clinical School, University of Sydney, Canberra Hospital, Australia.

Abstract

Epidemiological studies and case reports provide evidence for an association between Parkinson's disease and past exposure to pesticides. Susceptibility to the effects of pesticides and other putative neurotoxins depends on variability in xenobiotic metabolism possibly generated by genetic polymorphisms, aging and variation in exposure to environmental agents including pesticides. The simplest mechanistic hypothesis for the association of pesticides with Parkinson's disease is that pesticides or their metabolites are directly toxic to mitochondria, although modulation of xenobiotic metabolism by pesticides provides an adjunct or alternative hypothesis.

PMID:
10349500
DOI:
10.1016/S0753-3322(99)80077-8
[Indexed for MEDLINE]
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