Gilvusmycin, a new antitumor antibiotic related to CC-1065

Y Tokoro; T Isoe; K Shindo

doi:10.7164/antibiotics.52.263

Gilvusmycin, a new antitumor antibiotic related to CC-1065

J Antibiot (Tokyo). 1999 Mar;52(3):263-8. doi: 10.7164/antibiotics.52.263.

Authors

Y Tokoro¹, T Isoe, K Shindo

Affiliation

¹ Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.

PMID: 10348041
DOI: 10.7164/antibiotics.52.263

Abstract

A new antitumor antibiotic gilvusmycin was isolated from the culture broth of Streptomyces sp. QM16. The structure of gilvusmycin was related to CC-1065 and determined by NMR spectral analysis. Gilvusmycin exhibited antitumor activity against murine leukemia P388 in vivo.

MeSH terms

Animals
Antibiotics, Antineoplastic / isolation & purification*
Antibiotics, Antineoplastic / pharmacology
Culture Media
Drug Screening Assays, Antitumor
Fermentation
Humans
Indoles / isolation & purification
Indoles / pharmacology
Leukemia P388 / drug therapy
Magnetic Resonance Spectroscopy
Mice
Naphthoquinones / isolation & purification
Naphthoquinones / pharmacology
Spectrophotometry, Ultraviolet
Streptomyces / classification
Streptomyces / metabolism
Tumor Cells, Cultured

Substances

Antibiotics, Antineoplastic
Culture Media
Indoles
Naphthoquinones
lactonamycin