Format

Send to

Choose Destination
See comment in PubMed Commons below
J Clin Pathol. 1999 Jan;52(1):29-34.

Correlation between androgen receptor expression and FGF8 mRNA levels in patients with prostate cancer and benign prostatic hypertrophy.

Author information

1
Department of Histopathology, Imperial College School of Medicine, London, UK.

Abstract

AIM:

To investigate the correlation between androgen receptor expression and fibroblast growth factor 8 (FGF8) mRNA levels.

METHODS:

39 human prostate cancers and 14 benign prostatic hypertrophy specimens were examined immunohistochemically for androgen receptor expression and by in situ hybridisation and reverse transcription polymerase chain reaction for FGF8 expression.

RESULTS:

In 39 tumours there was a statistically significant negative correlation between tumour grade and FGF8 expression and a positive correlation between FGF8 and androgen receptor expression. All 14 benign hypertrophy specimens expressed moderate to high levels of FGF8 and androgen receptor.

CONCLUSIONS:

Loss of FGF8 may be a factor involved in the development of prostatic cancer.

PMID:
10343609
PMCID:
PMC501004
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center