Format

Send to

Choose Destination
See comment in PubMed Commons below
Semin Cancer Biol. 1999 Jun;9(3):211-20.

VEGFs, receptors and angiogenesis.

Author information

  • 1Molecular/Cancer Biology Laboratory, Haartman Institute (Haatmaninkatu 3), 00014 University of Helsinki, Finland.

Abstract

Angiogenesis, the formation of new blood vessels from pre--existing ones, is central for both normal development and homeostasis as well as in certain pathological conditions. The vascular endothelial growth factors (VEGFs) and their receptors are prime regulators of both physiological and pathological angiogenesis. The different VEGFs have overlapping but specific roles in controlling the growth of new blood vessels. The VEGF receptors transduce signals mediating endothelial cell proliferation, migration, organization into functional vessels and remodeling of the vessel network. In recent years, rapid progress has been made in understanding the receptor-ligand interactions that orchestrate the neovascularization process.

Copyright 1999 Academic Press.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk