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Bioorg Med Chem Lett. 1999 May 3;9(9):1329-34.

Synthesis of novel analogues of the delta opioid ligand SNC-80 using AlCl3-promoted aminolysis.

Author information

1
Organon Laboratories Ltd., Newhouse, Scotland, UK.

Abstract

Two focused libraries of delta opioid ligands were synthesised using AlCl3 facilitated aminolysis. Several compounds were identified with DOR binding affinities higher or similar to SNC-80. A novel acyclic derivative of SNC-80 produced antinociception in the acetic acid abdominal constriction test, which is at least partially mediated via the delta-opioid receptor.

PMID:
10340623
DOI:
10.1016/s0960-894x(99)00174-2
[Indexed for MEDLINE]

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