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Bioorg Med Chem Lett. 1999 May 3;9(9):1279-84.

Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF-alpha production.

Author information

1
The DuPont Pharmaceutical Co., Experimental Station, Wilmington, DE 19880-0500, USA.

Abstract

Several macrocyclic, hydroxamate derivatives were synthesized and evaluated as inhibitors of matrix metalloproteinases (MMPs) and tumour necrosis factor-alpha (TNF-alpha) production. These macrocycles are anti-succinate based inhibitors linked from P1 to P2'. A variety of functionality was installed at the P1-P2' linkage, which gave inhibitors that displayed excellent MMP inhibition and good TNF-alpha suppression.

PMID:
10340614
DOI:
10.1016/s0960-894x(99)00178-x
[Indexed for MEDLINE]

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