Format

Send to

Choose Destination
Infect Dis Clin North Am. 1999 Jun;13(2):413-26, ix.

Cytokines and anticytokines in the pathogenesis of sepsis.

Author information

1
Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.

Abstract

Clinical trials with anti-inflammatory agents in patients with sepsis are based on the assumption that excessive proinflammatory activity of the cytokine network negatively influences the outcome of severe bacterial infections. The failure of these trials to show clinical benefit, in conjunction with recent experimental data, raises doubt about the validity of this assumption. This article reevaluates the role of cytokines in the pathogenesis of sepsis and severe bacterial infections. The cytokine network is discussed as consisting of proinflammatory cytokines, antiinflammatory cytokines, and soluble inhibitors of proinflammatory cytokines.

PMID:
10340175
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center