Send to

Choose Destination
Infect Dis Clin North Am. 1999 Jun;13(2):285-97, vii.

Clinical trials for severe sepsis. Past failures, and future hopes.

Author information

Brown University School of Medicine, Providence, Rhode Island, USA.


Recent clinical trials with experimental immunotherapeutic agents for severe sepsis and septic shock have been largely unsuccessful despite seemingly convincing preclinical evidence of significant benefit of these antisepsis therapies. This article reviews basic therapeutic rationale, preclinical evaluation, and clinical trial design of past clinical trials of innovative sepsis treatments. Lessons learned from past failures should provide insights into the design and implementation of successful clinical trials for new anti-sepsis agents in the future.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center