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Clin Geriatr Med. 1999 May;15(2):255.

Glucotoxicity: potential mechanisms.

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Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri 63104, USA.


Plasma concentration of glucose is found within a relatively narrow range of values for most animal species, yet it has little correlation with maximum lifespan; however, hyperglycemia in most animals is associated with premature death. This article presents evidence for hyperglycemia-induced tissue toxicity and discusses potential mechanisms of glucotoxicity and implications for the aging organism.

[Indexed for MEDLINE]

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