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Curr Biol. 1999 May 20;9(10):R381-4.

Apoptosis: Silencing the death receptors.

Author information

1
Institute of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH - 1066, Epalinges, Switzerland. jurg.tschopp@ib.unil.ch

Abstract

Spontaneous signaling from death-domain-containing receptors can result in inappropriate cell death. An inhibitory protein has recently been identified, called silencer of death domains (SODD), that binds to the death domain of tumor necrosis factor receptor 1, thereby negatively regulating downstream signaling.

PMID:
10339421
[Indexed for MEDLINE]
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