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Vet Surg. 1999 May-Jun;28(3):135-40.

Possible hemolytic uremic syndrome in three cats after renal transplantation and cyclosporine therapy.

Author information

1
Veterinary Medical Teaching Hospital, Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, USA.

Abstract

OBJECTIVE:

To describe the clinical history of 3 cats with possible hemolytic uremic syndrome (HUS) after renal transplantation.

STUDY DESIGN:

This case series documents historical findings, physical examination findings, clinical pathologic features, necropsy and histopathologic findings of 3 cats with possible HUS.

RESULTS:

Two cats had chronic renal failure; 1 cat had acute renal failure secondary to ethylene glycol toxicity. A renal transplant was performed in each of the 3 cats without obvious problems. Complications that would support a diagnosis of HUS, including anemia, thrombocytopenia, and azotemia occurred within 24 hours in 1 cat, within 8 days in a second cat, and 2 months after transplantation in the third cat. In 2 cats, HUS was likely secondary to cyclosporine immunosuppression. In the third cat, HUS may have been secondary to allograft rejection. Renal biopsies from all 3 cats were suggestive of HUS.

CONCLUSION AND CLINICAL RELEVANCE:

In human beings, HUS in transplant recipients may occur secondary to immunosuppressive drugs, vascular rejection, or recurrence of original disease. Graft loss occurred in all 3 cats in this study and the mortality rate was 100%. Clinicians caring for these patients need to be aware of this disorder because early recognition and treatment is critical in the management of post-transplant HUS.

PMID:
10338157
[Indexed for MEDLINE]

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