Format

Send to

Choose Destination
See comment in PubMed Commons below
Eur J Surg Oncol. 1999 Jun;25(3):297-301.

p53 expression as a prognostic determinant in resected distal bile duct carcinoma.

Author information

  • 1Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.

Abstract

AIMS:

To determine the incidence and prognostic value of p53 immunopositivity in resectable distal bile duct carcinoma (DBDC).

METHODS:

Forty-seven paraffin-embedded archival tumour samples of patients with DBDC, who underwent subtotal pancreatoduodenectomy from 1985 to 1996, were immunohistochemically examined for p53 positivity, using the anti-p53 antibody D07.

RESULTS:

Nineteen (40%) of the 47 tumours demonstrated positive (>30%) p53 protein immunostaining. Focally positive or negative staining was seen in the remaining 28 (60%) cases. Patients in this low p53 category survived significantly longer than those in the high p53 category, with median survival durations of 29 and 13 months respectively (P=0. 039). p53 positivity was independent of age, sex, tumour size, radicality of resection, histopathological grading, lymph-node status, perineural invasion and vasoinvasive growth.

CONCLUSIONS:

This study indicates that low (0-30%) p53 expression is a favourable prognostic factor in patients with resected DBDC.

PMID:
10336811
DOI:
10.1053/ejso.1998.0645
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center